Highlights
- •This is the first time to investigate interleukin 10 (IL-10)-1082G/A gene polymorphism associated with the risk of acute lung injury/respiratory distress syndrome (ALI/RDS) by meta-analysis.
- •Allele G and genotype GG at IL-10-1082G/A locus could increase the ALI/RDS risk, especially in Asia.
- •Allele G, genotype GG+GA, GG, and GA at IL-10-1082G/A locus could increase the neonatal RDS risk.
Abstract
Background
Several records have reported that single nucleotide polymorphism (SNP) at the interleukin
10 (IL-10)-1082G/A locus affects the risk of acute lung injury/respiratory distress
syndrome (ALI/RDS), but the exact association between them has not been elucidated.
Objective
This systematic review aims to elucidate the relationship between SNP at the IL-10-1082G/A
locus and susceptibility to ALI/RDS by the method of meta-analysis, to identify the
early warning indicators of ALI/RDS.
Methods
Studies on IL-10-1082G/A SNP associated with ALI/RDS were obtained by thorough retrieval
of four English databases from each database construction to April 1, 2022. We processed
the data using Stata 15.0 software.
Results
Eight eligible records were entered into this meta-analysis. The pooled analysis demonstrated
that SNP at the IL-10-1082G/A locus contributed to the risk of ALI/RDS in the allelic
(G vs. A: OR= 0.74, 95%CI: 0.55∼0.98) and recessive gene models (Genotype GG vs. GA+AA:
OR= 0.57, 95%CI: 0.35∼0.93). The subgroup analysis based on case type showed that
SNP at IL-10-1082G/A locus contributed to the risk of neonatal respiratory distress
syndrome (NRDS) under all the gene models (Allele G vs. A: OR= 0.45, 95%CI: 0.29∼0.72;
Genotype GG+GA vs. AA: OR= 0.36, 95%CI: 0.22∼0.58; Genotype GG vs. GA+AA: OR= 0.30,
95%CI: 0.09∼0.97; Genotype GA vs. AA: OR= 0.44, 95%CI: 0.27∼0.73), except the homozygous
model. However, it was not found that SNP at the IL-10-1082G/A locus contributed to
ALI or acute respiratory distress syndrome (ARDS). Moreover, the risk of ALI/RDS in
Asia was associated with the IL-10-1082G/A locus in the allelic, recessive, and heterozygous
models, while we did not observe this association across the Caucasian populations.
Conclusion
SNP at the IL-10-1082G/A locus contributed to the risk of ALI/RDS, allele G and genotype
GG increasing the ALI/RDS risk, especially in Asia. Besides, allele G, genotype GG+GA,
GG, and GA at the IL-10-1082G/A locus can increase susceptibility to NRDS.
Keywords
Abbreviations:
ALI (acute lung injury), RDS (respiratory distress syndrome), NRDS (neonatal respiratory distress syndrome), ARDS (acute respiratory distress syndrome), PS (pulmonary surfactant), ECR1 (erythrocyte complement receptor 1), IL-10 (Interleukin 10), PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses), NOS (Newcastle-Ottawa Scale), OR (odds ratio), CI (confidence interval), FEM (fixed-effects model), REM (random-effects model), HWE (Hardy-Weinberg equilibrium), SNP (single nucleotide polymorphism)To read this article in full you will need to make a payment
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Article info
Publication history
Published online: December 13, 2022
Accepted:
November 30,
2022
Received in revised form:
November 29,
2022
Received:
April 29,
2022
Identification
Copyright
© 2022 Elsevier Inc. All rights reserved.
