Highlights
- •Of the total sample, 78% had in-hospital mortality.
- •Factors associated with in-hospital mortality from free wall rupture were first reported.
- •Pericardiocentesis, pericardial effusion at admission, the acute myocardial infarction to free wall rupture time, and previous myocardial infarction were associated factors.
Abstract
Background
Free wall rupture is a fatal and emergency complication of acute myocardial infarction.
The factors associated with in-hospital mortality from free wall rupture remain unclear.
Objectives
To investigate the factors associated with in-hospital mortality from free wall rupture.
Methods
We performed a single-center, retrospective study. We enrolled 111 consecutive patients
with free wall rupture following acute myocardial infarction who were admitted to
Fuwai Hospital from January 2005 to May 2021. The primary endpoint was in-hospital
death. Clinical characteristics, laboratory data, and treatment modalities associated
with in-hospital mortality were analyzed.
Results
Eighty-seven of the 111 study participants died in hospital. Multivariate Cox regression
analysis showed that pericardiocentesis (hazard ratio [HR] 0.296, 95% confidence interval
[CI] 0.094–0.929, p = 0.037), pericardial effusion at admission (HR 0.083, 95% CI 0.025–0.269, p<0.001), time interval between acute myocardial infarction and free wall rupture (HR
0.670, 95% CI 0.598–0.753, p<0.001), and previous myocardial infarction (HR 0.046, 95% CI 0.010–0.208, p<0.001) were independently associated with in-hospital mortality.
Conclusions
Pericardiocentesis, pericardial effusion at admission, the acute myocardial infarction
to free wall rupture time, and previous myocardial infarction are associated with
a lower rate of in-hospital mortality from free wall rupture after acute myocardial
infarction.
Keywords
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Article info
Publication history
Published online: October 12, 2022
Accepted:
October 5,
2022
Received in revised form:
August 9,
2022
Received:
June 15,
2022
Identification
Copyright
© 2022 Elsevier Inc. All rights reserved.
