Abstract
Background
There is limited research on clinical indicators for clinicians to judge the hypercoagulability
of COPD patients.
Objective
The aim in this study was to evaluate the level changes of fibrinogen (FIB), d-dimer (D-D), and mean platelet volume (MPV) in plasma during the stable phase of
chronic obstructive pulmonary disease (COPD), as compared with acute exacerbation
of COPD (AECOPD).
Methods
A total of 240 patients admitted with COPD in our hospital and 60 healthy people were
enrolled in this prospective study using data from August 2016 to August 2017. Patients
were allocated to AECOPD or stable COPD group. The levels of white blood cell (WBC)
count, absolute neutrophil counts (NEU%), activated partial thromboplastin time (APTT),
prothrombin time (PT), and hypoxia inducible factor-1(HIF-1) were detected. The MPV,
D-D, and the FIB level were also determined and compared between groups.
Results
The WBC count, NEU%, FIB, and D-D were significantly higher in the AECOPD group than
in the stable COPD group and the healthy group (P < 0.05), while the MPV, APTT and PT was significantly lower in the AECOPD group than
in the stable COPD group and the healthy group (P < 0.05). Additionally, MPV was significantly negatively correlated with WBC count
(r=-0.798) and NEU% (r=-0.749) in the AECOPD group (P < 0.05); and the percentage of forced expiratory volume in one second (FEV1) in the
predicted value was significantly negatively correlated with D-D (r=-0.891) and FIB (r=-0.656) (P <0.05).
Conclusion
We demonstrated that, for patients hospitalized for exacerbation of COPD, MPV may
indeed be a valid indicator of inflammation and a marker of thrombosis.
Keywords
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Article info
Publication history
Published online: August 31, 2022
Accepted:
August 19,
2022
Received in revised form:
August 18,
2022
Received:
February 22,
2022
Identification
Copyright
© 2022 Elsevier Inc. All rights reserved.
