Vanin-1 as a novel biomarker for chronic obstructive pulmonary disease

  • Author Footnotes
    1 The authors share the equal work.
    Xue Zhang
    1 The authors share the equal work.
    Department of Respiratory and Intensive Medicine, Daqing Oilfield General Hospital, 9 Zhongkang Street, Daqing 163001, China
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  • Author Footnotes
    1 The authors share the equal work.
    Wenchao Cong
    1 The authors share the equal work.
    Department of Respiratory and Intensive Medicine, Daqing Oilfield General Hospital, 9 Zhongkang Street, Daqing 163001, China
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  • Aiping Lu
    Corresponding author.
    Department of Respiratory Medicine, Daqing People's Hospital, 241 Jianshe Road, Daqing 163000, China
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  • Author Footnotes
    1 The authors share the equal work.



      The function of vascular non-inflammatory molecule 1 (Vanin-1), an enzyme essential for vitamin B5 synthesis, has not been studied yet in chronic obstructive pulmonary disease (COPD).


      In this study, we aimed to evaluate the expression of Vanin-1 in sera and lung tissues of COPD, and infer its possible roles in COPD.


      We collected blood and lung tissue specimens from 99 COPD patients and 62 non-COPD subjects. Enzyme-linked immunosorbent assay was used to determine levels of Vanin-1, pantothenic acid, interleukin-6 (IL-6), tumor necrotic factor α (TNFα), and reactive oxygen species (ROS). The receiver operating characteristics (ROC) curve was used for analysis of the diagnostic value of Vanin-1 in COPD patients. Pearson's correlation assay was used to determine the correlation between Vanin-1 and levels of inflammatory cytokines and ROS.


      Vanin-1 expression was significantly higher in the sera and lung tissues of COPD patients compared to non-COPD subjects. ROC analysis showed that the area under the curve (AUC) was greater than 0.5 for both sera (AUC = 0.7342) and lung tissues (AUC = 0.9061). Pantothenic acid was also upregulated in COPD patients. IL-6, TNFα and ROS showed strong positive correlations to Vanin-1 levels in sera.


      Vanin-1 upregulation in sera and lung tissue is a potentially valuable biomarker for COPD. Vanin-1 showed positive correlations to levels of pro-inflammatory cytokines and ROS. Together, our results support the further development of Vanin-1 as a new target for the diagnosis or treatment of COPD.


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