Abstract
Background
We have a limited understanding of the biological underpinnings of symptoms in heart
failure (HF).
Objectives
The purpose of this paper was to compare relationships between peripheral biomarkers
of HF pathogenesis and physical symptoms between patients with advanced versus moderate
HF.
Methods
This was a two-stage phenotype sampling cohort study wherein we examined patients
with advanced HF undergoing ventricular assist device implantation in the first stage,
and then patients with moderate HF (matched adults with HF not requiring device implantation)
in the second stage. Linear modeling was used to compare relationships among biomarkers
and physical symptoms between cohorts.
Results
Worse myocardial stress, systemic inflammation and endothelial dysfunction were associated
with worse physical symptoms in moderate HF (n=48), but less physical symptom burden in advanced HF (n=48).
Conclusions
Where patients are in the HF trajectory needs to be taken into consideration when
exploring biological underpinnings of physical HF symptoms.
Keywords
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Article info
Publication history
Published online: October 09, 2018
Accepted:
September 7,
2018
Received in revised form:
September 6,
2018
Received:
June 23,
2018
Identification
Copyright
© 2018 Elsevier Inc. All rights reserved.
