Abstract
This study was aimed at a serial evaluation of the prognostic values of initial shockable
rhythm, bystander cardiopulmonary resuscitation (CPR) and gender for neurological
outcome and survival in adults treated with targeted temperature management (TTM)
following cardiac arrest (CA). PubMed, Embase and the Cochrane Library were searched
for eligible studies. Pooled odds ratio (OR) with 95% confidence intervals (CIs) was
calculated to evaluate prognostic values using RevMan 5.3. The outcomes were favorable
neurological outcome (defined as cerebral performance category of 1 and 2) and survival.
Seventeen studies were subjected to the meta-analysis. Favorable neurological outcome
was associated with significantly higher odds of an initial shockable rhythm (OR:
7.63, 95%CI: 6.51–8.96), bystander CPR (OR: 1.44, 95%CI: 1.14–1.82), male (OR: 1.39,
95%CI: 1.20–1.61). Survival was associated with higher odds of an initial shockable
rhythm (OR: 4.88, 95%CI: 3.18–4.79), higher odds of bystander CPR (OR: 1.71, 95%CI:
1.05–2.77). No significant association was found between survival and male. In adult
patients treated with TTM, initial shockable rhythm, bystander CPR and male sex were
associated with a higher likelihood of favorable neurological outcome. Initial shockable
rhythm and bystander CPR were associated with a higher likelihood of survival. These
factors could help in identifying patients who are eligible for TTM.
Keywords
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Article info
Publication history
Published online: August 14, 2018
Accepted:
July 11,
2018
Received in revised form:
July 3,
2018
Received:
April 15,
2018
Footnotes
Conflict of interest: The authors declare that there is no conflict of interest.
Funding: None.
Identification
Copyright
© 2018 Elsevier Inc. All rights reserved.
