Abstract
Background
The relationship between physical heart failure (HF) symptoms and pathophysiological
mechanisms is unclear.
Objective
To quantify the relationship between plasma β-adrenergic receptor kinase-1 (βARK1)
and physical symptoms among adults with HF.
Methods
We performed a secondary analysis of data collected from two studies of adults with
HF. Plasma βARK1 was quantified using an enzyme-linked immunosorbent assay. Physical
symptoms were measured with the HF Somatic Perception Scale (HFSPS). Generalized linear
modeling was used to quantify the relationship between βARK1 and HFSPS scores.
Results
The average age (n = 94) was 54.5 ± 13.1 years, 76.6% were male, and a majority (83.0%) had Class III
or IV HF. βARK1 was significantly associated with HFSPS scores (β = 0.22 ± 0.10, p = 0.038), adjusting for other predictors of physical symptoms (model R2 = 0.250, F(7, 70) = 3.34, p = 0.004).
Conclusions
Higher βARK1 is associated with worse physical HF symptoms, pinpointing a potential
pathophysiologic underpinning.
Keywords
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Article info
Publication history
Published online: May 23, 2018
Accepted:
May 4,
2018
Received:
March 14,
2018
Footnotes
Conflict of interests: None Declared.
Funding: The work reported in this study was funded by the National Institutes of Health/National Institute of Nursing Research (NIH/NINR) (F31NR015936; Denfeld) and through support from the Achievement Rewards for College Scientists program. The parent studies were supported by grants from the NIH/NINR (R01NR013492; Lee), the National Center for Advancing Translational Sciences of the National Institutes of Health (UL1TR000128), and the Oregon Health & Science University Hartford Center. Dr. Denfeld is currently supported as a Scholar of the Oregon Building Interdisciplinary Research Careers in Women's Health K12 Program funded by the Eunice Kennedy Shriver National Institute of Child Health & Human Development of the NIH under Award Number K12HD043488. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH.
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© 2018 Elsevier Inc. All rights reserved.
