Abstract
Background
Music listening has been shown to reduce anxiety, stress, and patient tolerance of
procedures. Music may also have beneficial effects on inflammatory biomarkers in intensive
care and post-operative patients, but the quality of evidence is not clear.
Objectives
We conducted a systematic review to evaluate the effects of music on inflammatory
biomarkers in intensive care, and post-operative patients.
Methods
A comprehensive search of the literature was performed. After screening 1570 references,
full text review of 26 studies was performed. Fourteen studies were selected for inclusion.
Results
Seven studies showed a significant decrease in cortisol levels, but the level of evidence
was low. Three studies had low risk of methodological bias, while 11 studies had high
risk of bias.
Conclusions
Music intervention may decrease cortisol levels, but other biomarkers remain unchanged.
Given the low level of evidence, further research on music effects on inflammatory
biomarkers is needed.
Keywords
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References
- Music interventions for mechanically ventilated patients.Cochrane Database Syst Rev. 2014; (Cd006902)
- The effectiveness of music as an intervention for hospital patients: a systematic review.J Adv Nurs. 2002; 37: 8-18
- Effects of patient-directed music intervention on anxiety and sedative exposure in critically ill patients receiving mechanical ventilatory support: a randomized clinical trial.JAMA. 2013; 309: 2335-2344
- The influence of music during mechanical ventilation and weaning from mechanical ventilation: a review.Heart Lung. 2015; 44: 416-425
- Music and emotions: from enchantment to entrainment.Ann N Y Acad Sci. 2015; 1337: 212-222
- Getting the beat: entrainment of brain activity by musical rhythm and pleasantness.Neuroimage. 2014; 103: 55-64
- Effects of music therapy on autonomic nervous system activity, incidence of heart failure events, and plasma cytokine and catecholamine levels in elderly patients with cerebrovascular disease and dementia.Int Heart J. 2009; 50: 95-110
- The neurochemistry of music.Trends Cogn Sci. 2013; 17: 179-193
- The psychoneuroimmunological effects of music: a systematic review and a new model.Brain Behav Immun. 2014; 36: 15-26
- Assessing the quality of reports of randomized clinical trials: is blinding necessary?.Control Clin Trials. 1996; 17: 1-12
- The hazards of scoring the quality of clinical trials for meta-analysis.JAMA. 1999; 282: 1054-1060
- The Cochrane Collaboration's tool for assessing risk of bias in randomised trials.BMJ. 2011; 343: d5928
- Cochrane handbook for systematic reviews of interventions version 5.1.0.2011
- Grading quality of evidence and strength of recommendations.BMJ. 2004; 328: 1490
- Music and biological stress dampening in mechanically-ventilated patients at the intensive care unit ward-a prospective interventional randomized crossover trial.J Crit Care. 2013; 28: 442-450
- Effects of music listening on cortisol levels and propofol consumption during spinal anesthesia.Front Psychol. 2011; 2: 58
- The effect of music on the neurohormonal stress response to surgery under general anesthesia.Anesth Analg. 2004; 98: 527-532
- The effect of music intervention in stress response to cardiac surgery in a randomized clinical trial.Heart Lung. 2009; 38: 201-207
- Soothing music can increase oxytocin levels during bed rest after open-heart surgery: a randomised control trial.J Clin Nurs. 2009; 18: 2153-2161
- Influence of music on the stress response in patients receiving mechanical ventilatory support: a pilot study.Am J Crit Care. 2007; 16: 141-145
- Does music influence stress in mechanically ventilated patients?.Intensive Crit Care Nurs. 2013; 29: 121-127
- Perioperative music may reduce pain and fatigue in patients undergoing laparoscopic cholecystectomy.Acta Anaesthesiol Scand. 2013; 57: 1010-1016
- Randomized clinical trial examining the effect of music therapy in stress response to day surgery.Br J Surg. 2007; 94: 943-947
- Effects of music intervention on state anxiety and physiological indices in patients undergoing mechanical ventilation in the intensive care unit.Biol Res Nurs. 2017; 19: 137-144
- Stress reduction and analgesia in patients exposed to calming music postoperatively: a randomized controlled trial.Eur J Anaesthesiol. 2005; 22: 96-102
Article info
Publication history
Published online: July 09, 2018
Accepted:
May 18,
2018
Received:
February 6,
2018
Footnotes
Conflict of interests: None declared.
Funding: SK is supported by NHBLI 5T32HL091816-07. MB is supported by NIA R01 AG040220-05, AHRQ P30 HS024384-02, CMS 1 L1 CMS331444-02-00 and NIA R01 AG030618-05A1. BK is supported by NIA K23-AG043476. LC is supported by NHLBI R01 HL130881-01.
Author Contributions: SK: data analysis, manuscript writing, study design; MK: data analysis, manuscript revision; DG: manuscript revision; SW: manuscript revision; LC: manuscript revision and technical insight; MB: manuscript revision and critical analysis; BK: study design, manuscript revision and critical analysis.
Reprints: Not anticipated.
Identification
Copyright
© 2018 Elsevier Inc. All rights reserved.
