Intermittent positive pressure ventilation increases diastolic pulmonary arterial pressure in advanced COPD

Published:November 20, 2014DOI:



      To measure the impact of intermittent positive pressure ventilation (IPPV) on diastolic pulmonary arterial pressure (dPAP) and pulmonary pulse pressure in patients with advanced COPD.


      The physiological effects of raised intrathoracic pressures upon the pulmonary circulation have not been fully established.


      22 subjects with severe COPD receiving IPPV were prospectively assessed with pulmonary and radial arterial catheterization. Changes in dPAP were assessed from end-expiration to early inspiration during low and high tidal volume ventilation.


      Inspiration during low tidal volume IPPV increased the median [IQR] dPAP by 3.9 [2.5–4.8] mm Hg (P < 0.001). During high tidal volume, similar changes were observed. The IPPV-associated change in dPAP was correlated with baseline measures of PaO2 (rho = 0.65, P = 0.005), pH (rho = 0.64, P = 0.006) and right atrial pressure (rho = −0.53, P = 0.011).


      In severe COPD, IPPV increases dPAP and reduces pulmonary pulse pressure during inspiration.



      Ax-surgery time (time duration between lung transplant assessment and lung transplant surgery), BMI (body mass index), CI (right ventricular cardiac index), COPD (chronic obstructive pulmonary disease), dBP (diastolic systemic arterial blood pressure), dPAP (diastolic pulmonary arterial pressure), FEV1 (forced expiratory volume in one second), FiO2 (fraction of inspired oxygen), FRC (functional residual capacity), FVC (forced vital capacity), HR (Heart rate), I:E (inspiratory to expiratory), IC (inspiratory capacity), IPAP (inspiratory positive airway pressure), IPPV (intermittent positive pressure ventilation), mPAP (mean pulmonary arterial pressure), PAWP (Pulmonary arterial wedge pressure), PEEPE (extrinsic positive end-expiratory pressure), PVR (pulmonary vascular resistance), RAP (right atrial pressure), RR (respiratory rate), RV (residual volume), sBP (systolic systemic arterial blood pressure), sPAP (systolic pulmonary arterial pressure), SVI (right ventricular stroke volume index), TLC (total lung capacity), TLCOhb (transfer factor of the lung for carbon monoxide corrected for hemoglobin), VT (tidal volume)
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