Objective
The admission of patients with cystic fibrosis (CF) to the intensive care unit (ICU)
is controversial. Our aim was to study the long-term outcome of patients with CF who
were admitted to the ICU and the effect of ventilation modality.
Methods
The medical records of 104 admissions (1996-2006) of 48 patients with CF (age 18±9 years) were reviewed. Seventeen patients were admitted with reversible conditions
(group 1). Thirty-one patients were admitted for acute on chronic respiratory failure
(group 2).
Results
In group 1, 16 of 17 patients survived up to 10 years from ICU admission. Conversely,
in group 2, 23 of 31 patients (74%) died of respiratory failure. In group 2, 17 of
18 patients who were mechanically ventilated died within 90 days from admission, and
7 of 10 patients treated for prolonged periods with bi-level positive airway pressure
are still alive up to 10 years after admission and transplantation.
Conclusion
Patients requiring mechanical ventilation may have a poor prognosis. The outcome of
treatment with bi-level positive airway pressure is good, even in patients who had
many episodes of acute respiratory failure.
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Article info
Publication history
Published online: August 26, 2009
Footnotes
Conflict of interest statement: There is no conflict of interest relating to the authors of this article.
Funding: None.
Identification
Copyright
© 2010 Elsevier Inc. Published by Elsevier Inc. All rights reserved.
