The purpose of this study was to determine which beta-adrenoceptor agonist (1 or 2)
is responsible for the direct inotropic effects on diaphragmatic contractility during
sepsis. Rats were divided into two groups: a cecal ligation and perforation (CLP)
group and a sham group. The hemidiaphragm was removed at 16 hours after the operation.
Dobutamine (a beta-1 agonist) or terbutaline (a beta-2 agonist) was administered to
an organ bath containing diaphragmatic tissues, and muscle contractility was assessed.
Muscle contractility was diminished in the CLP group. Terbutaline increased peak twitch
tension, caused an upward shift in the force-frequency curves, and improved contractility
of the fatigued diaphragm in the CLP group. Dobutamine did not have any effect on
these parameters in the CLP group. We conclude that activation of beta-2 adrenoceptors
might be responsible for the direct inotropic effects on the diaphragm in an intra-abdominal
septic model.
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Article info
Footnotes
This study was supported by grants-in-aid for scientific research (No. 13770848, 15591648 and 15591915) from the Japanese Ministry of Education, Science, Sports and Culture.
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Copyright
© 2007 Mosby, Inc. Published by Elsevier Inc. All rights reserved.
