Heart & Lung: The Journal of Acute and Critical Care
Volume 40, Issue 3 , Pages e78-e83 , May 2011

Pregnancy-associated plasma protein predicts outcomes of percutaneous coronary intervention in patients with non–ST-elevation acute coronary syndrome

  • Wei-Yi Mei, MD, PhD

      Affiliations

    • Department of Cardiology, Huangpu Division of The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, PR China
    • ,
  • Zhi-Min Du, MD

      Affiliations

    • Department of Cardiology, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, PR China
    • ,
  • Qiang Zhao, MD, PhD

      Affiliations

    • Department of Cardiology, The Red Cross Hospital of Guangzhou City, Fourth Affiliated Hospital of Jinan University, Guangzhou, PR China
    • ,
  • Cheng-Heng Hu, MD

      Affiliations

    • Department of Cardiology, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, PR China
    • ,
  • Yi Li

      Affiliations

    • Department of Cardiology, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, PR China
    • ,
  • Chu-Fan Luo, MD

      Affiliations

    • Department of Cardiology, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, PR China
    • ,
  • Gui-Fu Wu, MD

      Affiliations

    • Department of Cardiology, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, PR China
    • ,
  • Guo-Wei Chen, MD

      Affiliations

    • Department of Cardiology, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, PR China
    • ,
  • Le-Xin Wang, MD, PhD

      Affiliations

    • School of Biomedical Sciences, Charles Sturt University, Wagga Wagga, NSW, Australia
    • Corresponding Author InformationCorresponding author: Lexin Wang, MD, PhD, School of Biomedical Sciences, Charles Sturt University, Wagga Wagga, NSW 2678, Australia.

References 

  1. Bayes-Genis A, Conover CA, Bailey KR, et al. Pregnancy-associated plasma protein A as a marker of acute coronary syndromes. N Engl J Med. 2001;345:1022–1029
  2. Liu ZY, Zhang JY, Sun TW, Zhang YJ, Zhang L, Wang LX. Levels of pregnancy-associated plasma protein A and insulin-like growth factor-1 in patients with coronary artery disease. Clin Invest Med. 2008;31:E85–E89
  3. Cosin-Sales J, Kaski JC, Christiansen M, et al. Relationship among pregnancy associated plasma protein-A levels, clinical characteristics, and coronary artery disease extent in patients with chronic stable angina pectoris. Eur Heart J. 2005;26:2093–2098
  4. Cosin-Sales J, Christiansen M, Kaminski P, et al. Pregnancy-associated plasma protein A and its endogenous inhibitor, the proform of eosinophil major basic protein (proMBP), are related to complex stenosis morphology in patients with stable angina pectoris. Circulation. 2004;109:1724–1728
  5. Lund J, Qin QP, Ilva T, et al. Circulating pregnancy-associated plasma protein predicts outcome inpatients with acute coronary syndrome but no troponin I elevation. Circulation. 2003;108:1924–1926
  6. Heeschen C, Dimmeler S, Hamm CW, et al. Investigators CS. Pregnancy-associated plasma protein-A levels inpatients with acute coronary syndromes: comparison with markers of systemic inflammation, platelet activation, and myocardial necrosis. J Am Coll Cardiol. 2005;45:229–237
  7. Qin QP, Laitinen P, Majamaa-Voltti K, Eriksson S, Kumpula EK, Pettersson K. Release patterns of pregnancy associated plasma protein A (PAPP-A) in patients with acute coronary syndromes. Scand Cardiovasc J. 2002;36:358–361
  8. Overgaard MT, Haaning J, Boldt HB, et al. Expression of recombinant human pregnancy-associated plasma protein-A and identification of the proform of eosinophil major basic protein as its physiological inhibitor. J Biol Chem. 2000;275:31128–31133
  9. The TIMI. Study Group. The thrombolysis in myocardial infarction (TIMI) trial: phase I findings. N Engl J Med. 1985;312:932–936
  10. Gibson CM, Cannon CP, Murphy SA, et al. Relationship of TIMI myocardial perfusion grade to mortality after administration of thrombolytic drugs. Circulation. 2000;101:125–130
  11. Elesber AA, Lerman A, Denktas AE, et al. Pregnancy associated plasma protein-A and risk stratification of patients presenting with chest pain in the emergency department. Int J Cardiol. 2007;117:365–369
  12. Libby P. Current concepts of the pathogenesis of the acute coronary syndromes. Circulation. 2001;104:365–372
  13. Jones JI, Prevette T, Gockerman A, Clemmons DR. Ligand occupancy of the alfa-V-beta3 integrin is necessary for smooth muscle cells to migrate in response to insulin-like growth factor. Proc Natl Acad Sci U S A. 1996;93:2482–2487
  14. Iversen KK, Teisner AS, Teisner B, et al. Pregnancy associated plasma protein A, a potential marker for vulnerable plaque in patients with non-ST-segment elevation acute coronary syndrome. Clin Biochem. 2009;42:828–834
  15. Smith SC, Feldman TE, Hirshfeld JW, et al. ACC/AHA/SCAI 2005 guideline update for percutaneous coronary intervention: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (ACC/AHA/SCAI Writing Committee to Update the 2001 Guidelines for Percutaneous Coronary Intervention). J Am Coll Cardiol. 2006;47:e1–e121
  16. Chew DP, Bhatt DL, Robbins MA, et al. Incremental prognostic value of elevated baseline C-reactive protein among established markers of risk in percutaneous coronary intervention. Circulation. 2001;104:992–997
  17. Razzouk L, Muntner P, Bansilal S, et al. C-reactive protein predicts long-term mortality independently of low-density lipoprotein cholesterol in patients undergoing percutaneous coronary intervention. Am Heart J. 2009;158:277–283
  18. Li XP, Zhou SH, Tang JJ, et al. Association between plasma pregnancy-associated plasma protein A and restenosis after percutaneous coronary angioplasty. Circ J. 2008;72:729–733

 This study was supported by a grant from Guangdong Science and Technology Foundation (No. 2008A030201011) and Guangdong Medical Scientific Research Foundation (No. A2008176).

 This study followed the local ethics guidelines for human research and was approved by the institutional review board of the First Affiliated Hospital of Sun Yat-Sen University.

PII: S0147-9563(10)00277-3

doi: 10.1016/j.hrtlng.2010.06.006

Heart & Lung: The Journal of Acute and Critical Care
Volume 40, Issue 3 , Pages e78-e83 , May 2011

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