Heart & Lung: The Journal of Acute and Critical Care
Volume 40, Issue 5 , Pages 454-461 , September 2011

Deleterious impact of mild anemia on survival of young adult patients (age 45 ± 14 years) with idiopathic dilated cardiomyopathy: Data from the Trieste Cardiomyopathies Registry

  • Aneta Aleksova, MD, MSc

      Affiliations

    • Cardiovascular Department, “Ospedali Riuniti” and University of Trieste, Trieste, Italy
    • Corresponding Author InformationCorresponding author: Aneta Aleksova, MD, MSc, Cardiovascular Department, “Ospedali Riuniti” and University of Trieste, Via Valdoni 1, 34100 Trieste, Italy.
    • ,
  • Giulia Barbati, PhD

      Affiliations

    • Cardiovascular Department, “Ospedali Riuniti” and University of Trieste, Trieste, Italy
    • ,
  • Marco Merlo, MD

      Affiliations

    • Cardiovascular Department, “Ospedali Riuniti” and University of Trieste, Trieste, Italy
    • ,
  • Davide Stolfo, MD

      Affiliations

    • Cardiovascular Department, “Ospedali Riuniti” and University of Trieste, Trieste, Italy
    • ,
  • Gastone Sabbadini, MD

      Affiliations

    • Department of Clinical Morphological and Technological Sciences, University of Trieste, Trieste, Italy
    • ,
  • Andrea Di Lenarda, MD, FESC

      Affiliations

    • Cardiovascular Center, Azienda per i Servizi Sanitari N°1 of Trieste, Trieste, Italy
    • ,
  • Gianfranco Sinagra, MD, FESC

      Affiliations

    • Cardiovascular Department, “Ospedali Riuniti” and University of Trieste, Trieste, Italy

References 

  1. Bardy GH, Lee KL, Mark DB, et al. Sudden Cardiac Death in Heart Failure Trial (SCD-HeFT) Investigators. Amiodarone or an implantable cardioverter-defibrillator for congestive heart failure. N Engl J Med. 2005;352:225–237
  2. Task Force for Diagnosis and Treatment of Acute and Chronic Heart Failure 2008 of European Society of Cardiology. ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure 2008: the Task Force for the Diagnosis and Treatment of Acute and Chronic Heart Failure 2008 of the European Society of Cardiology. Eur Heart J. 2008;29:2388–2442
  3. Anand I, McMurray JJ, Whitmore J, et al. Anemia and its relationship to clinical outcome in heart failure. Circulation. 2004;110:149–154
  4. Ralli S, Horwich TB, Fonarow GC. Relationship between anemia, cardiac troponin I, and B-type natriuretic peptide levels and mortality in patients with advanced heart failure. Am Heart J. 2005;150:1220–1227
  5. Felker GM, Shaw LK, Stough WG, O'Connor CM. Anemia in patients with heart failure and preserved systolic function. Am Heart J. 2006;151:457–462
  6. Grigorian Shamagian L, Varela RA, Garcia-Acuna JM, Mazon RP, Virgos LA, Gonzalez-Juanatey JR. Anaemia is associated with higher mortality among patients with heart failure with preserved systolic function. Heart. 2006;92:780–784
  7. Newton JD, Squire IB. Glucose and haemoglobin in the assessment of prognosis after first hospitalisation for heart failure. Heart. 2006;92:1441–1446
  8. Schou M, Gustafsson F, Kistorp CN, Corell P, Kjaer A, Hildebrandt PR. Prognostic usefulness of anemia and N-terminal pro-brain natriuretic peptide in outpatients with systolic heart failure. Am J Cardiol. 2007;100:1571–1576
  9. Kosiborod M, Curtis JP, Wang Y, et al. Anemia and outcomes in patients with heart failure: a study from the National Heart Care Project. Arch Intern Med. 2005;165:2237–2244
  10. Formiga F, Chivite D, Castaner O, Manito N, Ramon JM, Pujol R. Anemia in new-onset congestive heart failure inpatients admitted for acute decompensation. Eur J Intern Med. 2006;17:179–184
  11. Gardner RS, Chong KS, Morton JJ, McDonagh TA. N-terminal brain natriuretic peptide, but not anemia, is a powerful predictor of mortality in advanced heart failure. J Card Fail. 2005;11:S47–S53
  12. Silva RP, Barbosa PH, Kimura OS, et al. Prevalence of anemia and its association with cardio-renal syndrome. Int J Cardiol. 2007;120:232–236
  13. Tigen K, Karaahmet T, Cevik C, Gurel E, Mutlu B, Basaran Y. Prognostic utility of anemia and pro-B-type natriuretic peptide in patients with nonischemic dilated cardiomyopathy and normal renal function. Am J Med Sci. 2009;337:109–115
  14. Richardson P, McKenna W, Bristow M, et al. Report of the 1995 World Health Organization/International Society and Federation of Cardiology Task Force on the definition and classification of cardiomyopathies. Circulation. 1996;93:841–842
  15. Aretz HT. Myocarditis: the Dallas criteria. Hum Pathol. 1987;18:619–624
  16. World Health Organization. Nutritional anaemias: report of a WHO Scientific Group. Geneva, Switzerland: World Health Organization; 1968;
  17. Spain MG, Smith MD, Grayburn PA, Harlamert EA, DeMaria AN. Quantitative assessment of mitral regurgitation by Doppler color flow imaging: angiographic and hemodynamic correlations. J Am Coll Cardiol. 1989;13:585–590
  18. Appleton CP, Hatle LK, Popp RL. Relation of transmitral flow velocity patterns to left ventricular diastolic function: new insights from a combined hemodynamic and Doppler echocardiographic study. J Am Coll Cardiol. 1988;12:426–440
  19. Cockcroft DW, Gault MH. Prediction of creatinine clearance from serum creatinine. Nephron. 1976;16:31–41
  20. Levey AS, Eckardt KU, Tsukamoto Y, et al. Definition and classification of chronic kidney disease: a position statement from Kidney Disease: improving Global Outcomes (KDIGO). Kidney Int. 2005;67:2089–2100
  21. McCullough PA, Lepor NE. Piecing together the evidence on anemia: the link between chronic kidney disease and cardiovascular disease. Rev Cardiovasc Med. 2005;6(Suppl 3):S4–S12
  22. Tang YD, Katz SD. Anemia in chronic heart failure: prevalence, etiology, clinical correlates, and treatment options. Circulation. 2006;113:2454–2461
  23. Androne AS, Katz SD, Lund L, et al. Hemodilution is common in patients with advanced heart failure. Circulation. 2003;107:226–229
  24. Ishani A, Weinhandl E, Zhao Z, et al. Angiotensin-converting enzyme inhibitor as a risk factor for the development of anemia, and the impact of incident anemia on mortality in patients with left ventricular dysfunction. J Am Coll Cardiol. 2005;45:391–399
  25. Komajda M, Anker SD, Charlesworth A, et al. The impact of new onset anaemia on morbidity and mortality in chronic heart failure: results from COMET. Eur Heart J. 2006;27:1440–1446
  26. Mann DL. Inflammatory mediators and the failing heart: past, present, and the foreseeable future. Circ Res. 2002;91:988–998
  27. Anand IS, Rector T, Deswal A, et al. Relationship between proinflammatory cytokines and anemia in heart failure. Eur Heart J. 2006;27(Suppl 1):485.
  28. Deswal A, Petersen NJ, Feldman AM, Young JB, White BG, Mann DL. Cytokines and cytokine receptors in advanced heart failure: an analysis of the cytokine database from the Vesnarinone trial (VEST). Circulation. 2001;103:2055–2059
  29. Torre-Amione G, Bozkurt B, Deswal A, Mann DL. An overview of tumor necrosis factor alpha and the failing human heart. Curr Opin Cardiol. 1999;14:206–210
  30. Macdougall IC, Cooper AC. Erythropoietin resistance: the role of inflammation and pro-inflammatory cytokines. Nephrol Dial Transplant. 2002;17(Suppl 11):39–43
  31. Weiss G, Goodnough LT. Anemia of chronic disease. N Engl J Med. 2005;352:1011–1023
  32. Jelkmann W. Proinflammatory cytokines lowering erythropoietin production. J Interferon Cytokine Res. 1998;18:555–559
  33. Horwich TB, Fonarow GC, Hamilton MA, MacLellan WR, Borenstein J. Anemia is associated with worse symptoms, greater impairment in functional capacity and a significant increase in mortality in patients with advanced heart failure. J Am Coll Cardiol. 2002;39:1780–1786
  34. Anand IS, Chandrashekhar Y, Ferrari R, Poole-Wilson PA, Harris PC. Pathogenesis of oedema in chronic severe anaemia: studies of body water and sodium, renal function, haemodynamic variables, and plasma hormones. Br Heart J. 1993;70:357–362
  35. McMurray JJ, Anand IS, Diaz R, et al. RED-HF Committees and Investigators. Design of the Reduction of Events with Darbepoetin alfa in Heart Failure (RED-HF): a Phase III, anaemia correction, morbidity-mortality trial. Eur J Heart Fail. 2009;11:795–801

 Conflict of Interest: none declared.

PII: S0147-9563(10)00213-X

doi: 10.1016/j.hrtlng.2010.06.001

Heart & Lung: The Journal of Acute and Critical Care
Volume 40, Issue 5 , Pages 454-461 , September 2011

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