Heart & Lung: The Journal of Acute and Critical Care
Volume 39, Issue 1 , Pages 21-26 , January 2010

Thrombocytopenia and outcome in critically ill patients with bloodstream infection

  • Dominique M. Vandijck, RN, MSc, MA, PhD

      Affiliations

    • Department of Intensive Care Medicine, Ghent University Hospital, Ghent, Belgium
    • Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium
    • Corresponding Author InformationCorresponding author: Dominique M. Vandijck, RN, MSc, MA, Department of Intensive Care Medicine, Faculty of Medicine and Health Sciences, Ghent University and Ghent University Hospital, De Pintelaan 185, 9000 Ghent, Belgium.
    • ,
  • Stijn I. Blot, RN, MSc, PhD

      Affiliations

    • Department of Intensive Care Medicine, Ghent University Hospital, Ghent, Belgium
    • ,
  • Jan J. De Waele, MD, PhD

      Affiliations

    • Department of Intensive Care Medicine, Ghent University Hospital, Ghent, Belgium
    • ,
  • Eric A. Hoste, MD, PhD

      Affiliations

    • Department of Intensive Care Medicine, Ghent University Hospital, Ghent, Belgium
    • ,
  • Koenraad H. Vandewoude, MD, PhD

      Affiliations

    • Department of Intensive Care Medicine, Ghent University Hospital, Ghent, Belgium
    • ,
  • Johan M. Decruyenaere, MD, PhD

      Affiliations

    • Department of Intensive Care Medicine, Ghent University Hospital, Ghent, Belgium

References 

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  2. Strauss R, Wehler M, Mehler K, Kreutzer D, Koebnick C, Hahn EG. Thrombocytopenia in patients in the medical intensive care unit: bleeding prevalence, transfusion requirements, and outcome. Crit Care Med. 2002;30:1765–1771
  3. Vanderschueren S, De Weerdt A, Malbrain M, Vankersschaever D, Frans E, Wilmer A, et al. Thrombocytopenia and prognosis in intensive care. Crit Care Med. 2000;28:1871–1876
  4. Blot SI, Depuydt P, Annemans L, Benoit D, Hoste E, De Waele JJ, et al. Clinical and economic outcomes in critically ill patients with nosocomial catheter-related bloodstream infections. Clin Infect Dis. 2005;41:1591–1598
  5. Blot SI, Vandewoude KH, Hoste EA, Colardyn FA. Outcome and attributable mortality in critically ill patients with bacteremia involving methicillin-susceptible and methicillin-resistant Staphylococcus aureus. Arch Intern Med. 2002;162:2229–2235
  6. Vincent JL, de Mendonca A, Cantraine F, Moreno R, Takala J, Suter PM, et al. Use of the SOFA score to assess the incidence of organ dysfunction/failure in intensive care units: results of a multicenter, prospective study. Working Group on “Sepsis-Related Problems” of the European Society of Intensive Care Medicine. Crit Care Med. 1998;26:1793–1800
  7. Hoste EA, Vandijck DM, Van Holder RC, De Waele JJ, Lameire NH, Claus S, et al. Health implications of antimicrobial-resistance in bloodstream infection patients with acute kidney injury. Infect Control Hosp Epidemiol. 2007;28:1107–1110
  8. Ibrahim EH, Sherman G, Ward S, Fraser VJ, Kollef MH. The influence of inadequate antimicrobial treatment of bloodstream infections on patient outcomes in the ICU setting. Chest. 2000;118:146–155
  9. Colardyn F. Appropriate and timely empirical antimicrobial treatment of ICU infections—a role for carbapenems. Acta Clin Belg. 2005;60:51–62
  10. Blot S, Vandewoude K, De Bacquer D, Colardyn F. Nosocomial bacteremia caused by antibiotic-resistant gram-negative bacteria in critically ill patients: clinical outcome and length of hospitalization. Clin Infect Dis. 2002;34:1600–1606
  11. Crowther MA, Cook DJ, Meade MO, Griffith LE, Guyatt GH, Arnold DM, et al. Thrombocytopenia in medical-surgical critically ill patients: prevalence, incidence, and risk factors. J Crit Care. 2005;20:348–353
  12. Levy MM, Fink MP, Marshall JC, Abraham E, Angus D, Cook D, et al. 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference. Crit Care Med. 2003;31:1250–1256
  13. Akca S, Haji-Michael P, de Mendonca A, Suter P, Levi M, Vincent JL. Time course of platelet counts in critically ill patients. Crit Care Med. 2002;30:753–756
  14. George JN, Raskob GE, Shah SR, Rizvi MA, Hamilton SA, Osborne S, et al. Drug-induced thrombocytopenia: a systematic review of published case reports. Ann Intern Med. 1998;129:886–890
  15. Levi M, Opal SM. Coagulation abnormalities in critically ill patients. Crit Care. 2006;10:222
  16. Niemi TT, Backman JT, Syrjala MT, Viinikka LU, Rosenberg PH. Platelet dysfunction after intravenous ketorolac or propacetamol. Acta Anaesthesiol Scand. 2000;44:69–74
  17. Levi M. Platelets in sepsis. Hematology. 2005;10(Suppl 1):129–131
  18. Russwurm S, Vickers J, Meier-Hellmann A, Spangenberg P, Bredle D, Reinhart K, et al. Platelet and leukocyte activation correlate with the severity of septic organ dysfunction. Shock. 2002;17:263–268
  19. Vandijck DM, Blot SI, Decruyenaere JM. The value of sepsis definitions in daily ICU-practice. Acta Clin Belg. 2006;61:219–225
  20. Vandijck DM, Blot SI, De Waele JJ, Hoste EA, Vandewoude KH, Decruyenaere JM. Thrombocytopenia as a marker of poor outcome in ICU patients with severe bloodstream infection. Crit Care Med. 2007;34(Suppl 1):A137
  21. Nijsten MW, ten Duis HJ, Zijlstra JG, Porte RJ, Zwaveling JH, Paling JC, et al. Blunted rise in platelet count in critically ill patients is associated with worse outcome. Crit Care Med. 2000;28:3843–3846
  22. Arnold DM, Crowther MA, Cook RJ, Sigouin C, Heddle NM, Molnar L, et al. Utilization of platelet transfusions in the intensive care unit: indications, transfusion triggers, and platelet count responses. Transfusion. 2006;46:1286–1291
  23. Spapen HD, Hachimi-Idrissi S, Corne L, Huyghens LP. Diagnostic markers of sepsis in the emergency department. Acta Clin Belg. 2006;61:138–142

PII: S0147-9563(09)00184-8

doi: 10.1016/j.hrtlng.2009.07.005

Heart & Lung: The Journal of Acute and Critical Care
Volume 39, Issue 1 , Pages 21-26 , January 2010

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