Heart & Lung: The Journal of Acute and Critical Care
Volume 39, Issue 3 , Pages 208-216 , May 2010

Peak body temperature predicts mortality in critically ill patients without cerebral damage

  • Panagiotis Kiekkas, RN, MSc, PhD

      Affiliations

    • Department of Anesthesiology and Critical Care Medicine, Patras University Hospital, Patras, Greece
    • Corresponding Author InformationCorresponding author: Panagiotis Kiekkas, RN, MSc, PhD, Intensive Care Unit, Department of Anesthesiology and Critical Care Medicine, Patras University Hospital, 76 Stratigou Konstantinopoulou Str., Aroi, Patras 263-31, Greece.
    • ,
  • Dimitrios Velissaris, MD, PhD

      Affiliations

    • Department of Anesthesiology and Critical Care Medicine, Patras University Hospital, Patras, Greece
    • ,
  • Menelaos Karanikolas, MD, MPH

      Affiliations

    • Department of Anesthesiology and Critical Care Medicine, Patras University Hospital, Patras, Greece
    • ,
  • Diamanto Aretha, MD

      Affiliations

    • Department of Anesthesiology and Critical Care Medicine, Patras University Hospital, Patras, Greece
    • ,
  • Adamantios Samios, RN

      Affiliations

    • Department of Anesthesiology and Critical Care Medicine, Patras University Hospital, Patras, Greece
    • ,
  • Chrisula Skartsani, RN

      Affiliations

    • Department of Anesthesiology and Critical Care Medicine, Patras University Hospital, Patras, Greece
    • ,
  • George I. Baltopoulos, MD, PhD

      Affiliations

    • School of Nursing, University of Athens, Athens, Greece
    • ,
  • Kriton S. Filos, MD, PhD

      Affiliations

    • Department of Anesthesiology and Critical Care Medicine, Patras University Hospital, Patras, Greece

References 

  1. Kluger MJ, Kozak W, Conn CA, Leon LR, Soszynski D. Role of fever in disease. Ann NY Acad Sci. 1998;856:224–233
  2. Kluger MJ, Kozak W, Conn CA, Leon LR, Soszynski D. The adaptive value of fever. Infect Dis Clin North Am. 1996;10:1–2
  3. Hasday JD, Singh IS. Fever and the heat shock response: distinct, partially overlapping processes. Cell Stress Chaperones. 2000;5:471–478
  4. Mackowiak PA, Plaisance KI. Benefits and risks of antipyretic therapy. Ann NY Acad Sci. 1998;856:214–223
  5. Oliveira-Filho J, Ezzeddine MA, Segal AZ, Buonanno FS, Chang Y, Ogilvy CS, et al. Fever in subarachnoid hemorrhage: relationship to vasospasm and outcome. Neurology. 2001;56:1299–1304
  6. Schwarz S, Hafner K, Aschoff A, Schwab S. Incidence and prognostic significance of fever following intracerebral hemorrhage. Neurology. 2000;54:354–361
  7. Commichau C, Scarmeas N, Mayer SA. Risk factors for fever in the neurologic intensive care unit. Neurology. 2003;60:837–841
  8. Diringer MN, Reaven NL, Funk SE, Uman GC. Elevated body temperature independently contributes to increased length of stay in neurologic intensive care unit patients. Crit Care Med. 2004;32:1489–1495
  9. Sacho RH, Childs C. The significance of altered temperature after traumatic brain injury: an analysis of investigations in experimental and human studies: part 2. Br J Neurosurg. 2008;22:497–507
  10. Marik PE. Fever in the ICU. Chest. 2000;117:855–869
  11. Circiumaru B, Baldock G, Cohen J. A prospective study of fever in the intensive care unit. Intensive Care Med. 1999;25:668–673
  12. Peres Bota D, Lopes Ferreira F, Melot C, Vincent JL. Body temperature alterations in the critically ill. Intensive Care Med. 2004;30:811–816
  13. Barie PS, Hydo LJ, Eachempati SR. Causes and consequences of fever complicating critical surgical illness. Surg Infect (Larchmt). 2004;5:145–159
  14. Laupland KB, Shahpori R, Kirkpatrick AW, Ross T, Gresgon DB, Stelfox HT. Occurrence and outcome of fever in critically ill adults. Crit Care Med. 2008;36:1531–1535
  15. Knaus WA, Draper EA, Wagner DP, Zimmerman JE. APACHE II: a severity of disease classification system. Crit Care Med. 1985;13:818–828
  16. Erickson RS. The continuing question of how best to measure body temperature. Crit Care Med. 1999;27:2307-1
  17. Erickson RS, Kirklin SK. Comparison of ear-based, bladder, oral, and axillary methods for core temperature measurement. Crit Care Med. 1993;21:1528–1534
  18. Lefrant J-Y, Muller L, Emmanuel Coussaye J, Benbabaali M, Lebris C, Zeitoun N, et al. Temperature measurements in intensive care patients: comparison of urinary bladder, oesophageal, rectal, axillary, and inguinal methods vs. pulmonary artery core method. Intensive Care Med. 2003;29:414–418
  19. O'Grady NP, Barie PS, Bartlett JG, Bleck T, Carroll K, Kalil AC, et al. Guidelines for evaluation of new fever in critically ill adult patients. 2008 update from the American College of Critical Care Medicine and the Infectious Diseases Society of America. Crit Care Med. 2008;36:1330–1349
  20. Garner JS, Jarvis WR, Emori TG, Horan TC, Hughes JM. CDC definitions for nosocomial infections, 1988. Am J Infect Control. 1988;16:128-4
  21. Roth J, Zeisberger E, Vybiral S, Jansky L. Endogenous antipyretics: neuropeptides and glucocorticoids. Front Biosci. 2004;9:816–826
  22. Bruder N, Raynal M, Pellissier D, Courtinat C, Francois G. Influence of body temperature, with or without sedation, on energy expenditure in severe head-injured patients. Crit Care Med. 1998;26:568–572
  23. Mackowiak PA, Boulant JA. Fever's glass ceiling. Clin Infect Dis. 1996;22:525–536
  24. Hasday JD, Fairchild KD, Shanholtz C. The role of fever in the infected host. Microbes Infect. 2000;2:1891–1904
  25. Cunha BA. Fever in the intensive care unit. Intensive Care Med. 1999;25:648–651
  26. Kiser JR, Koniaris LS, Edelman JD, St John Sutton MG. Pheochromocytoma crisis, cardiomyopathy, and hemodynamic collapse. Chest. 2000;118:1221–1223
  27. Osmon S, Warren D, Seiler SM, Shannon W, Fraser VJ, Kollef MH. The influence of infection on hospital mortality for patients requiring >48 h of intensive care. Chest. 2003;124:1021–1029
  28. Sanchez-Velazquez LD, Ponce de Leon Rosales S, Rangel Frausto MS. The burden of nosocomial infection in the intensive care unit: effects on organ failure, mortality and costs. A nested case-control study. Arch Med Res. 2006;37:370–375
  29. Jaber S, Chanques G, Altairac C, Sebanne M, Vergne C, Perrigault P-F, et al. A prospective study of agitation in a medical-surgical ICU: incidence, risk factors, and outcomes. Chest. 2005;128:2749–2757
  30. Aldemir M, Ozen S, Kara IH, Sir A, Bac B. Predisposing factors for delirium in the surgical intensive care unit. Crit Care. 2001;5:265–267
  31. Mancebo J. Weaning from mechanical ventilation. Eur Respir J. 1996;9:1923–1931
  32. Gozzoli V, Schottker P, Suter PM, Ricou B. Is it worth treating fever in intensive care unit patients?. Arch Intern Med. 2001;161:121–123
  33. Schulman CI, Namias N, Doherty J, Manning RJ, Li P, Alhaddad A, et al. The effect of antipyretic therapy upon outcomes in critically ill patients: a randomized, prospective study. Surg Infect (Larchmt). 2005;6:369–375

 This was a prospective, observational study, conducted at the 14-bed, medical-surgical Intensive Care Unit of Patras University Hospital, an academic, tertiary-care hospital in Patras, Greece.

PII: S0147-9563(09)00178-2

doi: 10.1016/j.hrtlng.2009.06.019

Heart & Lung: The Journal of Acute and Critical Care
Volume 39, Issue 3 , Pages 208-216 , May 2010

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