Heart & Lung: The Journal of Acute and Critical Care
Volume 39, Issue 2 , Pages 153-159 , March 2010

Outcome of patients with cystic fibrosis admitted to the intensive care unit: Is invasive mechanical ventilation a risk factor for death in patients waiting lung transplantation?

  • Ori Efrati, MD

      Affiliations

    • Pediatric Pulmonology Unit, The Edmond and Lili Safra Children's Hospital, Sheba Medical Center Ramat-Gan, Israel
    • Corresponding Author InformationReprint requests: Ori Efrati, MD, Pediatric Pulmonology Unit, Chaim Sheba Medical Center, Tel Hashomer 52621, Israel.
    • ,
  • Irena Bylin, MD

      Affiliations

    • Pediatric Pulmonology Unit, The Edmond and Lili Safra Children's Hospital, Sheba Medical Center Ramat-Gan, Israel
    • ,
  • Eran Segal, MD

      Affiliations

    • Intensive Care Unit, Sheba Medical Center, Ramat-Gan, Israel
    • ,
  • Daphna Vilozni, PhD

      Affiliations

    • Pediatric Pulmonology Unit, The Edmond and Lili Safra Children's Hospital, Sheba Medical Center Ramat-Gan, Israel
    • ,
  • Dalit Modan-Moses, MD

      Affiliations

    • Pediatric Pulmonology Unit, The Edmond and Lili Safra Children's Hospital, Sheba Medical Center Ramat-Gan, Israel
    • ,
  • Amir Vardi, MD

      Affiliations

    • Pediatric Intensive Care Unit, The Edmond and Lili Safra Children's Hospital, Sheba Medical Center, Ramat-Gan, Israel
    • ,
  • Amir Szeinberg, MD

      Affiliations

    • Pediatric Pulmonology Unit, The Edmond and Lili Safra Children's Hospital, Sheba Medical Center Ramat-Gan, Israel
    • ,
  • Gideon Paret, MD

      Affiliations

    • Pediatric Intensive Care Unit, The Edmond and Lili Safra Children's Hospital, Sheba Medical Center, Ramat-Gan, Israel

References 

  1. Liou TG, Adler FR, Cox DR, et al. Lung transplantation and survival in children with cystic fibrosis. N Engl J Med. 2007;357:2143–2152
  2. Rosenfeld M, Gibson RL, McNamara S, et al. Early pulmonary infection, inflammation, and clinical outcomes in infants with cystic fibrosis. Pediatr Pulmonol. 2001;32:356–366
  3. Davis PB, di Sant'Agnese PA. Assisted ventilation for patients with cystic fibrosis. JAMA. 1978;239:1851–1854
  4. Berlinski A, Fan LL, Kozinetz CA, Oermann CM. Invasive mechanical ventilation for acute respiratory failure in children with cystic fibrosis: outcome analysis and case-control study. Pediatr Pulmonol. 2002;34:297–303
  5. Bartz RR, Love RB, Leverson GE, Will LR, Welter DL, Meyer KC. Pre-transplant mechanical ventilation and outcome in patients with cystic fibrosis. J Heart Lung Transplant. 2003;22:433–438
  6. Efrati O, Modan-Moses D, Barak A, et al. Long-term non-invasive positive pressure ventilation among cystic fibrosis patients awaiting lung transplantation. Isr Med Assoc J. 2004;6:527–530
  7. Sood N, Paradowski LJ, Yankaskas JR. Outcomes of intensive care unit care in adults with cystic fibrosis. Am J Respir Crit Care Med. 2001;163:335–338
  8. Vedam H, Moriarty C, Torzillo PJ, et al. Improved outcomes of patients with cystic fibrosis admitted to the intensive care unit. J Cyst Fibros. 2004;3:8–14
  9. Efrati O, Kremer MR, Barak A, et al. Improved survival following lung transplantation with long-term use of bilevel positive pressure ventilation in cystic fibrosis. Lung. 2007;185:73–79
  10. Hodson ME, Madden BP, Steven MH, et al. Non-invasive mechanical ventilation for cystic fibrosis patients-a potential bridge to transplantation. Eur Respir J. 1991;4:524–527
  11. Yankaskas JR, Mallory GB. Lung transplantation in cystic fibrosis: consensus conference statement. Chest. 1998;113:217–226
  12. Elizur A, Sweet SC, Huddleston CB, et al. Pre-transplant mechanical ventilation increases short-term morbidity and mortality in pediatric patients with cystic fibrosis. J Heart Lung Transplant. 2007;26:127–131
  13. Ellaffi M, Vinsonneau C, Coste J, et al. One-year outcome after severe pulmonary exacerbation in adults with cystic fibrosis. Am J Respir Crit Care Med. 2005;171:158–164
  14. Aurora P, Lynn IM. Lung transplantation and end of life issues in cystic fibrosis. Paediatr Respir Rev. 2000;1:114–120
  15. Thomas SR. The pulmonary physician in critical care. Illustrative case: cystic fibrosis. Thorax. 2003;58:357–360
  16. Thomas SR, Evans TW, Geddes TW, et al. Cystic fibrosis in adults: outcome after admission to intensive care (Abstract). Pediatr Pulmonol. 2000;(Suppl):292
  17. Piper AJ, Parker S, Torzillo PJ, et al. Nocturnal nasal IPPV stabilizes patients with cystic fibrosis and hypercapnic respiratory failure. Chest. 1992;102:846–850
  18. Holland AE, Denehy L, Ntoumenopoulos G, et al. Non-invasive ventilation assists chest physiotherapy in adults with acute exacerbations of cystic fibrosis. Thorax. 2003;58:880–884
  19. Kerem E, Reisman J, Corey M, et al. Prediction of mortality in patients with cystic fibrosis. N Engl J Med. 1992;326:1187–1191
  20. Texereau J, Jamal D, Choukroun G, et al. Determinants of mortality for adults with cystic fibrosis admitted in Intensive Care Unit: a multicenter study. Respir Res. 2006;26:7–14
  21. Moffatt SD, Demers P, Robbins RC, et al. Lung transplantation: a decade of experience. J Heart Lung Transplant. 2005;24:145–151

 Conflict of interest statement: There is no conflict of interest relating to the authors of this article.

 Funding: None.

PII: S0147-9563(09)00160-5

doi: 10.1016/j.hrtlng.2009.06.014

Heart & Lung: The Journal of Acute and Critical Care
Volume 39, Issue 2 , Pages 153-159 , March 2010

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