Heart & Lung: The Journal of Acute and Critical Care
Volume 38, Issue 3 , Pages 176-181 , May 2009

Serum chlamydial lipopolysaccharide as a prognostic factor for a new cardiovascular event

  • Erkki Pesonen, MD, PhD

      Affiliations

    • Pediatric Cardiology, University Hospital of Lund, Sweden
    • Corresponding Author InformationCorresponding author: Erkki Pesonen, MD, PhD, Department of Pediatrics, Lund University Hospital, Getingevägen 4, SE-221 85 Lund, Sweden
    • ,
  • Terttu Tiirola, PhD

      Affiliations

    • National Public Health Institute, Oulu and Helsinki, Finland
    • ,
  • Eeva Andsberg, BM

      Affiliations

    • Pediatric Cardiology, University Hospital of Lund, Sweden
    • ,
  • Matti Jauhiainen, PhD

      Affiliations

    • National Public Health Institute, Oulu and Helsinki, Finland
    • ,
  • Matti Paldanius, MD, PhD

      Affiliations

    • National Public Health Institute, Oulu and Helsinki, Finland
    • ,
  • Kenneth Persson, MD, PhD

      Affiliations

    • Medical Microbiology, University Hospital of Malmö, Sweden
    • ,
  • Pekka Saikku, MD, PhD

      Affiliations

    • Department of Medical Microbiology, University of Oulu, Finland
    • ,
  • Seppo Sarna, D Soc Sc

      Affiliations

    • Department of Public Health, University of Helsinki, Finland
    • ,
  • Hans Öhlin, MD, PhD

      Affiliations

    • Cardiology, University Hospital of Lund, Sweden
    • ,
  • Maija Leinonen, PhD

      Affiliations

    • National Public Health Institute, Oulu and Helsinki, Finland

References 

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  13. Tiirola T, Sinisalo J, Nieminen MS, Silvennoinen-Kassinen S, Paldanius M, Saikku P, et al. Chlamydial lipopolysaccharide is present in serum during acute coronary syndrome and correlates with CRP levels. Atherosclerosis. 2007;194:403–407
  14. Pesonen E, Andsberg E, Öhlin H, Puolakkainen M, Rautelin H, Sarna S, et al. Dual role of infections as risk factors for coronary heart disease. Atherosclerosis. 2007;192:370–375
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  17. Härkönen P, Puolakkainen M, Sarvas M, Airaksinen U, Hovi T, Roivainen M. Picornavirus proteins share antigenic determinants with heat shock proteins 60/65. J Med Virol. 2000;62:383–391
  18. Roivainen M, Alfthan G, Jousilahti P, Kimpimaki M, Hovi T, Tuomilehto J. Enterovirus infections as a possible risk factor for myocardial infarction. Circulation. 1998;98:2534–2537
  19. Roivainen M. Enteroviruses and myocardial infarction. Am Heart J. 1999;138:S479–S483
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  21. Lajunen T, Vikatmaa P, Ikonen T, Lepäntalo M, Lounatmaa K, Sormunen R, et al. Comparison of polymerase chain reaction methods, in situ hybridization, and enzyme immunoassay for detection of Chlamydia pneumoniae in atherosclerotic carotid plaques. Diagn Microbiol Infect Dis. 2008;61:156–164
  22. Tiran A, Tio RA, Ossewaarde JM, Tiran B, den Heijer P, The TH, et al. Coronary angioplasty induces rise in Chlamydia pneumoniae-specific antibodies. J Clin Microbiol. 1999;37:1013–1017
  23. Leinonen M, Linnanmaki E, Mattila K, Nieminen MS, Valtonen V, Leirisalo-Repo M, et al. Circulating immune complexes containing chlamydial lipopolysaccharide in acute myocardial infarction. Microb Pathog. 1990;9:67–73
  24. Linnanmaki E, Leinonen M, Mattila K, Nieminen MS, Valtonen V, Saikku P. Chlamydia pneumoniae-specific circulating immune complexes in patients with chronic coronary heart disease. Circulation. 1993;87:1130–1134
  25. Wong YK, Dawkins KD, Ward ME. Circulating Chlamydia pneumoniae DNA as a predictor of coronary artery disease. J Am Coll Cardiol. 1999;34:1435–1439

 The study was supported by grants from Lund University, Lund University Hospital, Academy of Finland, and Finnish Funding Agency for Technology and Innovation.

PII: S0147-9563(08)00120-9

doi: 10.1016/j.hrtlng.2008.06.001

Heart & Lung: The Journal of Acute and Critical Care
Volume 38, Issue 3 , Pages 176-181 , May 2009

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