Heart & Lung: The Journal of Acute and Critical Care
Volume 38, Issue 1 , Pages 83-88 , January 2009

Fever of unknown origin (FUO) due to Rosai-Dorfman disease with mediastinal adenopathy mimicking lymphoma: Diagnostic importance of elevated serum ferritin levels and polyclonal gammopathy

  • Burke A. Cunha, MD

      Affiliations

    • Infectious Disease Division, Winthrop-University Hospital, Mineola, New York
    • State University of New York School of Medicine, Stony Brook, New York
    • Corresponding Author InformationCorresponding author: Burke A. Cunha, MD, Chief, Infectious Disease Division, Winthrop-University Hospital, Mineola, NY 11501
    • ,
  • Nicole Durie, MD

      Affiliations

    • State University of New York School of Medicine, Stony Brook, New York
    • ,
  • Elena Selbs, MD

      Affiliations

    • State University of New York School of Medicine, Stony Brook, New York
    • ,
  • Francisco Pherez, MD

      Affiliations

    • State University of New York School of Medicine, Stony Brook, New York

References 

  1. Petersdorf RG, Beeson PB. Fever of unexplained origin: report on 100 cases. Medicine. 1961;40:1–30
  2. In:  Cunha BA editors. Fever of unknown origin (FUO). New York: Informa Healthcare; 2007;
  3. Cunha BA. Fever in malignant disorders. Infect Dis Pract. 2004;26:335–336
  4. Cunha BA. Fever of unknown origin: clinical overview of classic and current concepts. Infect Dis Clin North Am. 2007;21:867–915
  5. Cunha BA. Fever of unknown origin: focused diagnostic approach based on clinical clues from the history, physical examination, and laboratory tests. Infect Dis Clin North Am. 2007;21:1137–1187
  6. Krol V, Cunha BA. Diagnostic significance of serum ferritin levels in infectious and non-infectious diseases. Infect Dis Pract. 2003;27:199–200
  7. Cunha BA. Fever of unknown origin (FUO): diagnostic importance of serum ferritin levels. Scand J Infect Dis. 2007;39:651–652
  8. Cunha BA. Polyclonal gammopathy on SPEP. Infect Dis Pract. 1996;20:39–40
  9. Rosai J, Dorfman RF. Sinus histiocytosis with massive lymphadenopathy (A newly recognized benign clinicopathologic entity). Arch Pathol. 1969;87:63–70
  10. Sanchez R, Rosai J, Dorfman RF. Sinus histiocytosis with massive lymphadenopathy: an analysis of 113 cases with special emphasis on its extranodal manifestations. Lab Invest. 1977;36:21
  11. Rosai J, Dorfman RF. Sinus histiocytosis with massive lymphadenopathy: a pseudolymphomatous benign disorder (Analysis of 34 cases). Cancer. 1972;30:1174–1188
  12. Foucar E, Rosai J, Dorfman R. Sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease): review of the entity. Semin Diagn Pathol. 1990;7:19–73
  13. Rosai J. Sinus histiocytosis with massive lymphadenopathy. Am J Surg Pathol. 1991;15:191–192
  14. Carbone A, Devaney KO, Passannante A, et al. Clinicopathological consultation review of sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease) of Head and Neck. Ann Otol Rhinol Laryngol. 1999;108:1095–1104
  15. Sacchi S, Artusi T, Torelli U, Emilia G. Sinus histiocytosis with massive lymphadenopathy. Leuk Lymphoma. 1992;7:189–194
  16. Bhat GM, Kumar S, Sharma A. Rosai-Dorfman disease: a case report with review of literature. Ind J Med Pediatr Oncol. 2004;25:39–41
  17. Eisen RN, Buckley PJ, Rosai J. Immunophenotypic characterization of sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease). Semin Diagn Pathol. 1990;7:74–82
  18. Komp DM. The treatment of sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease). Semin Diagn Pathol. 1990;7:83–86
  19. Falk S, Stutte HJ, Frizzera G. Hodgkin's disease and sinus histiocytosis with massive lymphadenopathy-like changes. Histopathology. 1991;19:221–224
  20. Jaffe ES. Histiocytosis of lymph nodes: biology and differential diagnosis. Semin Diagn Pathol. 1988;5:376–390
  21. Reed JC. Chest radiology: plain film patterns and differential diagnosis. In: (3rd ed). St Louis: Mosby; 1991;p. 83–145
  22. Cunha BA. Pneumonia essentials. (2nd ed). Royal Oak, MI: Physicians Press; 2008;

PII: S0147-9563(08)00056-3

doi: 10.1016/j.hrtlng.2008.03.001

Heart & Lung: The Journal of Acute and Critical Care
Volume 38, Issue 1 , Pages 83-88 , January 2009

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