Heart & Lung: The Journal of Acute and Critical Care
Volume 36, Issue 2 , Pages 140-147 , March 2007

Direct inotropic effect of the beta-2 receptor agonist terbutaline on impaired diaphragmatic contractility in septic rats

  • Mitsuru Uzuki, MD, PhD

      Affiliations

    • Department of Anesthesiology, Sapporo Medical University School of Medicine, Sapporo, Japan
    • ,
  • Michiaki Yamakage, MD, PhD

      Affiliations

    • Department of Anesthesiology, Sapporo Medical University School of Medicine, Sapporo, Japan
    • Corresponding Author InformationReprint requests: Michiaki Yamakage, MD, PhD, Assistant Professor, Department of Anesthesiology, Sapporo Medical University School of Medicine, South 1, West 16, Chuo-ku, Sapporo, Hokkaido 060-8543, Japan.
    • ,
  • Naoyuki Fujimura, MD, PhD

      Affiliations

    • Division of Emergency and Critical Care Medicine, Okayama University School of Medicine, Okayama, Japan.
    • ,
  • Akiyoshi Namiki, MD, PhD

      Affiliations

    • Department of Anesthesiology, Sapporo Medical University School of Medicine, Sapporo, Japan

References 

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  3. Boczkowski J, Dureuil B, Branger C, Pavlovic D, Murciano D, Pariente R, et al. Effect of sepsis on diaphragmatic function in rats. Am Rev Respir Dis. 1988;138:260–265
  4. Fujimura N, Sumita S, Natimatsu E. Alteration in diaphragmatic contractility during septic peritonitis in rats: effect of polyethylene glycol-absorbed superoxide dismutase. Crit Care Med. 2000;28:2406–2414
  5. Fujimura N, Sumita S, Aimono M, Masuda Y, Shichinohe Y, Narimatsu E, et al. Effect of free radical scavengers on diaphragmatic contractility in septic peritonitis. Am J Respir Crit Care Med. 2000;162:2159–2165
  6. Masuda Y, Sumita S, Fujimura N, Namiki A. Geranylgeranylacetone attenuates septic diaphragm dysfunction by induction of heat shock protein 70. Crit Care Med. 2003;31:2585–2591
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  23. Ebata T, Fujii Y, Toyooka H. Dobutamine increases diaphragmatic contractility in dogs. Can J Anaesth. 1992;39:375–380
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 This study was supported by grants-in-aid for scientific research (No. 13770848, 15591648 and 15591915) from the Japanese Ministry of Education, Science, Sports and Culture.

PII: S0147-9563(06)00178-6

doi: 10.1016/j.hrtlng.2006.06.006

Heart & Lung: The Journal of Acute and Critical Care
Volume 36, Issue 2 , Pages 140-147 , March 2007

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