Heart & Lung: The Journal of Acute and Critical Care
Volume 35, Issue 6 , Pages 423-426 , November 2006

Abciximab and fatal pulmonary hemorrhage

  • M. Haris U. Usman, MD

      Affiliations

    • Department of Internal Medicine, Drexel University College of Medicine, Darby, Pennsylvania
    • Corresponding Author InformationReprint requests: M. Haris U. Usman, MD, 151 South Bishop Avenue, Apartment A18, Secane PA 19018.
    • ,
  • Manzoor A. Shah, MD, MRCP (UK)

      Affiliations

    • Department of Internal Medicine, Drexel University College of Medicine, Darby, Pennsylvania
    • ,
  • Tasbir ul-Islam, MD, MRCP (UK)

      Affiliations

    • Department of Pulmonary Medicine and Critical Care, Winthrop University Hospital, Mineola, New York
    • ,
  • Humaira N. Adenwalla, MD

      Affiliations

    • Department of Internal Medicine, Drexel University College of Medicine, Darby, Pennsylvania
    • ,
  • Fahd Rahman, MD

      Affiliations

    • Department of Internal Medicine, Drexel University College of Medicine, Darby, Pennsylvania
    • ,
  • Misbah Baqir, MD

      Affiliations

    • Department of Internal Medicine, St. Anthony’s Central Hospital, Denver, Colorado
    • ,
  • Mujeeb Altaf, MD, MRCP (UK)

      Affiliations

    • Department of Internal Medicine, St. Mary’s Hospital, Yale School of Medicine, Waterbury, Connecticut.
    • ,
  • Rajesh Venkataraman, MD, MPH

      Affiliations

    • Department of Internal Medicine, Drexel University College of Medicine, Darby, Pennsylvania
    • ,
  • Marina Cherayil, MD

      Affiliations

    • Department of Internal Medicine, Drexel University College of Medicine, Darby, Pennsylvania
    • ,
  • Stanley Berger, MD, FACC

      Affiliations

    • Department of Cardiology, Mercy Catholic Medical Center, Drexel University College of Medicine, Darby, Pennsylvania

References 

  1. EPIC Investigators. Use of monoclonal antibody directed against platelet glycoprotein IIb/IIIa receptor in high-risk coronary angioplasty. N Engl J Med. 1994;330:956–961
  2. Montalescot G, Barragan P, Wittenberg O, et al. ADMIRAL Investigators platelet glycoprotein IIb/IIIa inhibition with coronary stenting for acute myocardial infarction. N Engl J Med. 2001;344:1895–1903
  3. Topol JE, Califf MR, Weisman FH, et al. Randomized trial of coronary intervention with antibody against platelet IIb/IIIa integrin for reduction of clinical restenosis: results at six months. (on behalf of the EPIC investigators) Lancet. 1994;343:881–886
  4. Chan AW, Chew DP, Bhatt DL, Moliterno DJ, Topol EJ, Ellis SG. Long term mortality benefit with the combination of stents and abciximab for cardiogenic shock complicating acute myocardial infarction. Am J Cardiol. 2002;89:132–136
  5. Brown DL. Deaths associated with platelet glycoprotein IIb/IIIa inhibitor treatment. Heart. 2003;89(5):535–537
  6. Cohen SA, Effron MB. Abciximab and alveolar hemorrhage. N Engl J Med. 1998;339:1861–1863
  7. Sitges M, Villa FP. Massive pulmonary hemorrhage in a patient treated with a platelet glycoprotein IIb/IIIa inhibitor. Int J Cardiol. 1997;62:269–271
  8. Aguirre FV, Topol EJ, Ferguson JJ, et al. EPIC Investigators Bleeding complications with the chimeric antibody to platelet glycoprotein IIb/IIIa integrin in patients undergoing percutaneous coronary intervention. Circulation. 1995;91:2882–2890
  9. Khanlou H, Tsiodras S, Eiger G, et al. Fatal alveolar hemorrhage and abciximab (ReoPro) therapy for acute myocardial infarction. Cathet Cardiovasc Diagn. 1998;44:313–331
  10. Ali A, Patil S, Grady KJ, Schreiber TL. Diffuse alveolar hemorrhage following administration of tirofiban or abciximab: a nemesis of platelet glycoprotein IIb/IIIa inhibitors. Catheter Cardiovasc Interv. 2000;49:181–184
  11. Kalra S, Bell MR, Rihal CS. Alveolar hemorrhage as a complication of treatment with abciximab. Chest. 2001;120:126–131
  12. EPILOG Investigators. Platelet glycoprotein IIb/IIIa receptor blockade and low dose heparin during percutaneous coronary revascularization. N Engl J Med. 1997;336:1689–1696
  13. Kilaru PK, Schweiger MJ, Kozman HA, Weil TR. Diffuse alveolar hemorrhage after clopidogrel use. J Invasive Cardiol. 2001;13:535–537
  14. Amanullah S, Mina B, Rogers M. Iced saline bronchoalveolar lavage—a potential therapeutic option for pulmonary hemorrhage after percutaneous coronary intervention (PCI). Chest. 2004;126:926S

PII: S0147-9563(06)00136-1

doi: 10.1016/j.hrtlng.2006.06.004

Heart & Lung: The Journal of Acute and Critical Care
Volume 35, Issue 6 , Pages 423-426 , November 2006

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