Heart & Lung: The Journal of Acute and Critical Care
Volume 35, Issue 3 , Pages 178-189 , May 2006

Functional recovery after neuromuscular blockade in mechanically ventilated critically ill patients

  • Janet G. Whetstone Foster, PhD, RN, CNS, CCRN

      Affiliations

    • Texas Woman’s University, Houston, Texas
    • Corresponding Author InformationReprint requests: Janet G. Whetstone Foster, PhD, RN, CNS, CCRN, Assistant Professor of Nursing, Texas Woman’s University, 1130 John Freeman Boulevard, Houston, TX 77030.
    • ,
  • Angela P. Clark, PhD, RN, CS, FAAN, FAHA

      Affiliations

    • The University of Texas at Austin, Austin, Texas.

References 

  1. Murray M , Cowen J , DeBlock H , Erstad B , Gray A , Tescher A , et al.   Clinical guidelines for sustained neuromuscular blockade in the adult critically ill patient . Crit Care Med . 2002;30:142–156
  2. MacFarlane IA , Rosenthal FD . Severe myopathy after status asthmaticus . Lancet . 1977;2:615
  3. Hoyt JW . Persistent paralysis in the intensive care unit. A clinical conundrum . Crit Care Med . 1994;2:1
  4. Rudis M , Angus E , Peterson E , Popovich J , Hyzy R , Zarowitz B . Vecuronium (V) dosing by peripheral nerve stimulation (PNS) reduces paralytic dosing requirements and recovery times in critically ill medical patients (a prospective, randomized controlled evaluation) . Crit Care Med . 1996;24(1 Suppl):A71
  5. Douglass J , Tuxen M , Horne C . Acute myopathy following treatment of severe life threatening asthma . Am Rev Respir Dis . 1990;141:A397
  6. Hanschen-Flaschen J , Cowen J , Raps E . Neuromuscular blockade in the intensive care unit more than we bargained for . Am Rev Respir Dis . 1993;147:234–236
  7. Latronic N , Fenzi F , Recupero D . Critical illness myopathy and neuropathy . Lancet . 1996;347:1579–1582
  8. Bowman WC . Physiology and pharmacology of neuromuscular blocking transmission, with special reference to the possible consequences of prolonged blockade . Intensive Care Med . 1993;19:S45–S53
  9. Zochdne DW , Ramsay D , Shelley S . Acute necrotizing myopathy of intensive care (electrophysiological studies) . Muscle Nerve . 1994;17:285–292
  10. Ghez C . The control of movement . In:  Kandel ER ,  Schwartz JH ,  Jessel TM editor. Principles of neural science . 4th edition. New York: McGraw-Hill, Health Professions Division; 2000;p. 533–547
  11. Wagner BKJ , O’Hara DA . Pharmacokinetics and pharmacodynamics of sedatives and analgesics in the treatment of critically ill patients . Clin Pharmacokinet . 1997;33:426–453
  12. Silverman DG , Standaert FG . Mechanisms of neuromuscular block . In:  Standaert DG editors. Neuromuscular block in perioperative and intensive care . Philadelphia: JB Lippincott; 1994;p. 11–22
  13. Foster J , Kish S , Keenan C . A national survey of critical care nurses’ practices related to administration of neuromuscular blocking agents . Am J Crit Care . 2001;10:139–145
  14. Gan TJ , Madan R , Alexander R . Duration of action of vecuronium after intubating dose of rapacuronium, vecuronium, or succinylcholine . Anesth Analg . 2001;92(5):1199–1202
  15. Caldwell JE , Szenohradszky J , Segredo V . The pharmacodynamics and pharmacokinetics of the metabolite 3-desacetylvecuronium (ORG7268) and its parent compound vecuronium in human volunteers . J Pharmacol Exp Ther . 1994;270(3):1216–1222
  16. Buck ML , Reed MD . Use of nondepolarizing agents in mechanically ventilated patients . Clin Pharmacol . 1991;10:32–48
  17. Leatherman JW , Fluegel WC , David WS , Davies SF , Iber C . Muscle weakness in mechanically ventilated patients with severe asthma . Am J Respir Care Med . 1996;153:1686–1690
  18. Torda T . The nature of gentamicin-induced neuromuscular block . Br J Anesth . 1980;52:325–328
  19. Viby-Mogensen J . Interaction of other drugs with muscle relaxants . Semin Anesth . 1985;4:52–64
  20. Segredo V , Caldwell JE , Matthay MA , Sharma ML , Gruenke LD . Pharmacokinetics of vecuronium after long-term administration . (abstract) Anesth Analg . 1990;70:S1–S450
  21. Silverman DG , Mirakhur RK . Effects of patient status and condition on nondepolarizing relaxants . In:  Standaert DG editors. Neuromuscular block in perioperative and intensive care . Philadelphia: JB Lippincott; 1994;p. 11–22
  22. Gooch JL , Suchyta MP , Balbierz JM , Petajan JH , Clemmer TP . Prolonged paralysis after treatment with neuromuscular blocking agents . Crit Care Med . 1991;19(9):1125–1131
  23. Kakulas BA , Mastaglia FL . Drug-induced, toxic and nutritional myopathies . In:  Mastaglia FL ,  Detchant LW editor. Skeletal muscle pathology . Edinburgh: Churchill Livingstone; 1992;p. 511–540
  24. Medical Research Council . Aids to the examination of the peripheral nervous system . London: Her Majesty’s Stationary Office; 1976;
  25. Tryon WW . Activity measurement in psychology and medicine . New York: Plenum Press; 1991;
  26. Patterson SM , Krantz DS , Montgomery LC , Deuster PA , Hedges SM , Nebel LE . Automated physical activity monitoring (validation and comparison with physiological and self-report measures) . Psychopathology . 1993;30:296–305
  27. Statistical Package for the Social Sciences. SPSS base 10.0 applications guide . Chicago: SPSS, Inc; 1999;
  28. Bercker S , Weber-Carstens S , Deja M , et al.   Critical illness polyneuropathy and myopathy in patients with acute respiratory distress syndrome . Crit Care Med . 2005;33(4):711–715
  29. Jacobi J , Fraser GL , Coursin DB , et al.   Clinical practice guidelines for the sustained use of sedatives and analgesics in the critically ill adult . Crit Care Med . 2002;30:119–140
  30. Kowalski SD , Rayfield CA . A post hoc descriptive study of patients receiving propofol . Am J Crit Care . 1999;8:507–513

 This research was supported by a grant provided by the American Association of Critical Care Nurses Houston-Gulf Coast Chapter.

PII: S0147-9563(05)00176-7

doi: 10.1016/j.hrtlng.2005.08.003

Heart & Lung: The Journal of Acute and Critical Care
Volume 35, Issue 3 , Pages 178-189 , May 2006

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