Heart & Lung: The Journal of Acute and Critical Care
Volume 32, Issue 2 , Pages 100-104 , March 2003

Case report: Dexatrim (Phenylpropanolamine) as a cause of myocardial infarction

References 

  1. Kernan WN, Viscoli CM, Brass LM, Broderick JP, Brott T, Feldmann E, et al.  Phenylpropanolamine and the risk of hemorrhagic stroke. NEJM. 2000;343:1826–1832
  2. Oosterbaan R, Burns MJ. Myocardial infarction associated with phenylpropanolamine. J Emerg Med. 2000;18:55–59
  3. Leo PJ, Hollander JE, Shih RD, Marcus SM. Phenylpropanolamine and associated myocardial injury. Ann Emerg Med. 1996;28:359–362
  4. Pentel PR, Mikell FL, Zavoral JH. Myocardial injury after phenylpropanolamine ingestion. Br Heart J. 1982;47:51–54
  5. Ferrari E, Taillan B, Tiger F, Gibelin P, Baudouy M, Camous JP, et al.  Ischémie myocardique aiguë après prise d'un vasoconstricteur. Ann Cardiol Angeiol. 1992;41:349
  6. Lake CR, Gallant S, Masson E, Miller P. Adverse drug effects attributed to phenylpropanolamine: A review of 142 case reports. Am J Med. 1990;89:195–208
  7. Lake CR, Rosenberg D, Quirk R. Phenylpropanolamine and caffeine use among diet center clients. Int J Obes. 1990;14:575–582
  8. FDA/Center for Drug Evaluation and Research. Available at http://www.fda.gov/cder/drug/infopage/ppa/default.htmFebruary 28, 2003; Accessed
  9. George VA, Johnson P. Weight loss behaviors and smoking in college students of diverse ethnicity. Am J Health Behav. 2001;25:115–124
  10. Mersfelder TL. Phenylpropanolamine and stroke: The study, the FDA ruling, the implications. Cleveland Clin J Med. 2001;68:208–223
  11. Martindale. The complete drug reference. 33rd ed/edited by Sean C. Sweetman. Pharmaceutical Press, London 2002 (online version accessed 11/02).
  12. Zaloga GP, Clark JD, Roberts PR. Inhibition of nitric oxide synthase enhances the myocardial toxicity of phenylpropanolamine. Crit Care Med. 2000;28:3679–3683
  13. Lake CR, Zaloga G, Bray J, Rosenberg D, Chernow B. Transient hypertension after two phenylpropanolamine diet aids and the effects of caffeine: A placebo controlled follow-up study. Am J Med. 1989;86:427–432
  14. Glick R, Hoying J, Cerullo L, Perlman S. Phenylpropanolamine: An over-the-counter drug causing central nervous system vasculitis and intracerebral hemorrhage. Case report and review. Neurosurgery. 1987;20:969–974
  15. Chouinard G, Ghadirian AM, Jones BD. Death attributed to ventricular arrhythmia induced by thioridazine in combination with a single Contac C capsule. Can Med Assoc J. 1978;119:729–730
  16. Pentel P. Toxicity of over-the-counter stimulants. JAMA. 1984;252:1898–1903
  17. Furchgott RF, Vanhoutte PM. Endothelium-derived relaxing and contracting factors. FASEB J. 1989;3:2007–2018
  18. Riddell DR, Owen JS. Nitric oxide and platelet aggregation. Vitam Horm. 1999;57:25–48
  19. Quyyumi AA, Dakak N, Andrews NP, Husain S, Arora S, Gilligan DM. Nitric oxide activity in the human coronary circulation: Impact of risk factors for coronary atherosclerosis. J Clin Invest. 1995;95:1747–1755
  20. Dinh-Xuan AT, Higenbottam TW, Clelland CA, Pepke-Zaba J, Cremona G, Butt AY, et al.  Impairment of endothelium dependent pulmonary artery relaxation in chronic obstructive lung disease. N Engl J Med. 1991;324:1539–1547
  21. Micromedex . Healthcare Series. Thomson Micromedex. 1974 - 2002;Vol 114: (online version accessed 11/02)

☆ Reprint requests: Florian H. Pilsczek, MD, Clinical Fellow in Infectious Diseases, Division of Infectious Diseases, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Kennedy-6, Boston, MA 02215.

☆☆ 0147-9563/2003/$30.00 + 0

PII: S0147-9563(03)00035-9

doi: 10.1067/mhl.2003.27

Heart & Lung: The Journal of Acute and Critical Care
Volume 32, Issue 2 , Pages 100-104 , March 2003

Article Tools